Microdialysis system

US6591126B2 · kind B2 · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Josef Roeper · Schifferstadt, DE
• Michael Schoemaker · Mannheim, DE
• Christian Hoerauf · Oftersheim, DE

Key dates

• Filing date: Jul 20, 2001
• Grant date: Jul 8, 2003
• Expiry date: Jul 20, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/14532
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention concerns a microdialysis system comprising a microdialysis probe (12) that can be inserted into organic tissue (10) and has a dialysis membrane (28) to separate a probe channel (18) filled with perfusion fluid from the tissue (10), a sensor cell (14) to determine the concentration of components and especially glucose in the perfusion fluid that is conveyed from the microdialysis probe (12) and a transport device (16) to convey the perfusion fluid through the probe channel (18) of the microdialysis probe (12) to the sensor cell (14). In order to enable a substantially pressureless transport of perfusion fluid through the microdialysis probe and thus to prevent undesired passage of fluid through the dialysis membrane (28), it is proposed that the transport device (16) has a pressure pump unit (30) connected on the pressure side to the inlet (20) of the probe channel (18) and a suction pump unit (31) connected on the suction side to the outlet (24) of the probe channel (18) that can be operated simultaneously with the pressure pump unit (30).