Intramolecularly-quenched near infrared flourescent probes
US6592847B1 · kind B1 · utility
105Cited by
15References
208Claims
0Family size
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Key dates
| Filing date | Jun 27, 2000 |
| Grant date | Jul 15, 2003 |
| Priority date | — |
| Expiry date | Jun 27, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/0068
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.