Hydrogel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules
US6592894B1 · kind B1 · utility
23Cited by
2References
38Claims
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Key dates
| Filing date | Jul 11, 2000 |
| Grant date | Jul 15, 2003 |
| Priority date | — |
| Expiry date | Jul 11, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.