Carcinogen assay
US6593084B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1998 |
| Grant date | Jul 15, 2003 |
| Priority date | — |
| Expiry date | Oct 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/136
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is drawn to methods and assays for the early determination of whether a test agent is a carcinogen. These novel methods and assays are used to correlate the pattern of differential gene expression from mammalian cells treated with the test agent with reference patterns of differential gene expression of mammalian cells treated with known carcinogens. Further, the present invention is drawn to methods of use of DNA and RNA isolated from the treated mammalian cells as well as kits comprising same. The present invention also is drawn to methods of determining whether a test agent is a carcinogen by measuring protein synthesis or post-translational modifications from mammalian cells treated with the test agent compared with mammalian cells treated with a known carcinogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.