Use of a RAR-&ggr;-specific agonist ligand for increasing the rate of apoptosis

US6593359B1 · kind B1 · utility

Assignee

• Centre International de Recherches Dermatalogiques Galderma (C.I.R.D.) Galderma · FR

Inventors

• Laszlo Fesus · Debrecen, HU
• Zsuzsa Szondy · Debrecen, HU
• Uwe Reichert · Schlüchtern, DE

Key dates

• Filing date: Jul 15, 1998
• Grant date: Jul 15, 2003
• Expiry date: Sep 11, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use of at least one &ggr;-RAR receptor-specific agonist ligand to prepare a pharmaceutical composition for increasing the rate of apoptosis in at least one cell population in which apoptosis may be induced by activating &ggr;-RAR receptors is disclosed. The composition is particularly useful for treating a disease or disorder related to an insufficient rate of apoptosis in at least one cell population in which apoptosis may be induced by activating &ggr;-RAR receptors. The use of at least one &ggr;-RAR receptor-specific agonist ligand as the apoptosis inducer in a cosmetic composition is also disclosed. Said composition may be used to prevent and/or control photo-ageing or chronological ageing of the skin.