Tubulin binding ligands and corresponding prodrug constructs

US6593374B2 · kind B2 · utility

Assignee

• Baylor University · US

Inventors

• Kevin G. Pinney · Woodway, US
• Vani P. Mocharla · Los Angeles, US
• Zhi Chen · Seattle, US
• Charles Garner · Waco, US
• Anjan Ghatak · Salt Lake City, US
• James M. Dorsey · Havertown, US

Key dates

• Filing date: Mar 12, 2001
• Grant date: Jul 15, 2003
• Expiry date: Jul 27, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl—aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, and phosphoramidates capable of demonstrating selective targeting and destruction of tumor cell vasculature.