Tumor necrosis factor peptide binding antibodies
US6593458B1 · kind B1 · utility
92Cited by
13References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 13, 2000 |
| Grant date | Jul 15, 2003 |
| Priority date | — |
| Expiry date | Dec 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are isolated antibodies or fragments thereof which bind a peptide consisting of residues Leu63-Phe64-Lys65-Gly66-Gln67-Gly68-Cys69-Pro70-Ser71-Thr72-His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83 (peptide 304) of mature human TNF-&agr;. The antibodies and fragments thereof may be used to identify antibodies capable of binding in the region of mature human TNF-&agr; of amino acid resides 63-83. Antibodies or fragments thereof which bind particular regions of mature human TNF-&agr; are shown to elicit particular biological activities dependent upon the particular region wherein binding occurs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.