Stereospecific hydrolysis of optically active esters
US6593478B2 · kind B2 · utility
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Key dates
| Filing date | Jun 24, 2002 |
| Grant date | Jul 15, 2003 |
| Priority date | — |
| Expiry date | Jun 24, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new, more efficient and highly stereospecific process is described for the preparation of compounds with general formula (R)-(I) and of absolute configuration (R), where the groups M, W, Q and Q1 are as defined in the description, starting from compounds of absolute configuration (S) by hydrolysis, in the presence of acids, of the corresponding esterified derivatives. The (R)-(I) products obtained with the process described herein are chiral synthons useful for the production of enanthiomerically pure drugs. The preparation of (R)-carnitine is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.