Models of chronic and acute inflammatory diseases
US6593511B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 9, 2001 |
| Grant date | Jul 15, 2003 |
| Priority date | — |
| Expiry date | May 9, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5088
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and compositions are provided for the creation and screening of non-human animal models having chronic inflammation. Immunocompromised host animals are injected with a population of immunocompetent effector cells, depleted of CD25+ T cells. The effector cells are tolerant of the host major histocompatibility antigens, but reactive to at least one antigen present in the host animal. The transferred cells are preferably stimulated and localized by administration of an immunostimulant at a local site. The animals are useful for a variety of screening assays and for investigation into disease causes and pathways. A variety of chronic inflammatory diseases may be studied with this model, including psoriasis, rheumatoid arthritis, diabetes, inflammatory bowel disease and multiple sclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.