Detection and visualization of neoplastic tissues and other tissues
US6596257B2 · kind B2 · utility
24Cited by
253References
27Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 22, 2000 |
| Grant date | Jul 22, 2003 |
| Priority date | — |
| Expiry date | Dec 22, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/582
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Kits containing the diagnostic systems and diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems include compositions containing conjugates that include a tissue specific, particularly a tumor-specific, targeting agent linked to a targeted agent, a luciferase or luciferin. The systems also include a second composition that contains the remaining components of a bioluminescence generating reaction. Administration of the compositions results production of light by targeted tissues that permits the detection and localization of neoplastic tissue for surgical removal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.