Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
US6596304B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 2000 |
| Grant date | Jul 22, 2003 |
| Priority date | — |
| Expiry date | Jul 11, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L31/044
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 &mgr;m to less than 100 &mgr;m thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 &mgr;m to 300 &mgr;m and a thickness of 0.2 cm to 1.5 cm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.