Fibrin tissue adhesive formulation and process for its preparation

US6596318B2 · kind B2 · utility

Assignee

• Glatt Process Technology GmbH · DE

Inventors

• Armin Prasch · Glückstadt, DE
• Bernhard Luy · Glückstadt, DE

Key dates

• Filing date: Apr 26, 2001
• Grant date: Jul 22, 2003
• Expiry date: Apr 26, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L24/043
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.