Compounds derived from an amine nucleus and pharmaceutical compositions comprising same

US6596747B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Chunjian Liu · Pennington, US
• T. G. Murali Dhar · Newtown, US
• Henry H. Gu · Bordentown, US
• Edwin J. Iwanowicz · Cranbury, US
• Katerina Leftheris · Skillman, US
• William J. Pitts · Newtown, US
• Timothy Herpin · Princeton, US
• Gregory S. Bisacchi · Lawrenceville, US

Key dates

• Filing date: Nov 29, 2001
• Grant date: Jul 22, 2003
• Expiry date: Nov 29, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme and/or serine protease Factor VIIa, wherein B is a monocyclic or bicyclic carbocyclic or heterocyclic ring, D is a monocyclic or bicyclic carbocyclic or heterocyclic ring except when A is a heterocyclic ring, then D is a heterocyclic ring system, R is hydrogen or C1-4alkyl, and A, R1, R2 and R4 are as defined in the specification.