Process for preparing a multicombinatorial library of vectors for expressing antibody genes
US6599697B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 4, 1996 |
| Grant date | Jul 29, 2003 |
| Priority date | — |
| Expiry date | Oct 4, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
On the basis of a first repertoire of genes coding for a population of one of two kinds of polypeptides capable of being combined, particularly an antibody light chain variable region, and at least one gene, and preferably a second repertoire coding for the other kind of polypeptide, particularly an antibody heavy chain variable region, the genes from the first repertoire are inserted into a first vector to form a vector population and the genes from the second repertoire are inserted into a second vector, at least one of said vectors being a recipient for the expression of both genes as polypeptides irreversibly combined with the outer surface of the product of said vector.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.