Stable factor VIII compositions
US6599724B1 · kind B1 · utility
30Cited by
3References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 12, 2000 |
| Grant date | Jul 29, 2003 |
| Priority date | — |
| Expiry date | Jul 12, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a pharmaceutical composition comprising Factor VIII and the divalent metal ions Zn2+ and Cu2+, optionally in the presence of Ca2+ ions and/or Mn2+ ions, wherein said Factor VIII is stable without the addition of albumin. The invention also relates to a method for the production of recombinant Factor VIII from mammalian cells carrying the gene therefor, comprising culturing said mammalian cells in medium free of plasma-derived protein and supplemented with divalent metal ions, including Cu2+ and Zn2+, and optionally in the presence of Ca2+ and Mn2+ ions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.