Processes for preparing clarithromycin polymorphs and novel polymorph IV
US6599884B2 · kind B2 · utility
18Cited by
23References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 15, 2000 |
| Grant date | Jul 29, 2003 |
| Priority date | — |
| Expiry date | Dec 15, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to processes for converting clarithromycin Form 0 to clarithromycin Form II, which include slurrying clarithromycin the Form 0 in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form 0 to clarithromycin Form II by slurrying. The present invention further relates to the novel clarithromycin polymorph Form IV, a process for its preparation, pharmaceutical compositions comprising the compound, and methods of using the compound as a therapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.