Coniosetin and derivatives thereof, process for the preparation and the use thereof

US6599930B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Laszlo Vertesy · Eppstein, DE
• Martin Knauf · Frankfurt, DE
• Astrid Markus-Erb · Liederbach, DE
• Luigi Toti · Hochheim, DE
• Marie-Cecile Raynal-Wetzel · Paris, FR
• Florence Fassy · Paris, FR

Key dates

• Filing date: Dec 6, 2001
• Grant date: Jul 29, 2003
• Expiry date: Dec 6, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel active substances (coniosetin and coniosetin derivatives) of the formula I which are produced by the microorganism Coniochaeta ellipsoidea Udagawa (DSM 13856) during fermentation, wherein R, R2, R3, R4, R5, X, X2, X3 and X4 have the meanings stated in the specification, to chemical derivatives of coniosetin, to a process for their preparation and to their use as pharmaceuticals.