Alpha, beta-unsaturated sulfones for treating proliferative disorders

US6599932B1 · kind B1 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• E. Premkumar Reddy · Villanova, US
• M. V. Ramana Reddy · Upper Darby, US

Key dates

• Filing date: Nov 21, 2002
• Grant date: Jul 29, 2003
• Expiry date: Nov 21, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/48
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Sulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: wherein:Q1 is selected from the group consisting of(a) a phenyl radical according to formula II  whereinR1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl;(b) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl; and(c) an aromatic radical according to formula III  whereinn1 is 1 or 2,Y1 and Y2 are independently selected from the group consisting of hydrogen, halogen, and nitro, andX1 is selected from the group consisting of oxygen, nitrogen, sulfur and andQ2 is selected from the group consisting of(d) a phenyl radical according to formula II, as defined above;(e) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl;(f) an aromatic radical according to formula IV  whereinn1 is 1 or 2,Y3 and Y4 are independently selected from the group consisting of hydrogen, halogen, and nitro, andX2, X3 and X4 are independently selected from…