Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same

US6600010B2 · kind B2 · utility

Assignees

• Guilford Pharmaceuticals, Inc. · US
• The John Hopkins University · US

Inventors

• Hai-Quan Mao · Singapore, SG
• Kam W. Leong · Ellicott City, US
• Wenbin Dang · Baltimore, US
• Hungnan Lo · Shaker Heights, US
• Zhong Zhao · Munich, DE
• David P. Nowotnik · Kingsville, US
• James P. English · Birmingham, US

Key dates

• Filing date: Aug 2, 2001
• Grant date: Jul 29, 2003
• Expiry date: Aug 2, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T442/3545
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety;R′ is an aliphatic, aromatic or heterocyclic residue;x is ≧1; andn is 0-5,000,wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.