Tricyclic base analogues

US6600028B1 · kind B1 · utility

Assignee

• Amersham Pharmacia Biotech UK Limited · GB

Inventors

• Daniel Brown · Cambridge, GB
• David Loakes · Cambridge, GB
• David A. Williams · Glen Ellyn, US
• Fergal Hill · Riom, FR
• Shiv Kumar · Montgomery, US
• Satyam Nampalli · Cockeysville, US
• Mark McDougall · Bethlehem, US
• Alan Hamilton · Norton, GB
• Clifford Smith · Hertford, GB
• Adrian Simmonds · Norton, GB
• William Jonathan Cummins · Tring, GB
• Patrick Finn · North Riverside, US

Key dates

• Filing date: Feb 1, 2000
• Grant date: Jul 29, 2003
• Expiry date: Feb 1, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R8, X is O or N or NR12 or CR10, X′ is O or S or N, provided that when X′ is O or S, then X is C, Y is CH or N, R6 is NH2 or SMe or SO2Me or NHNH2, each of R7 and R8 is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R12 is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R10 is H or ═O or F or alkyl or aryl or a reporter moiety.