Process for the preparation of pyrimido[5,4-g]pteridine derivatives

US6600042B1 · kind B1 · utility

Assignee

• Ciba Specialty Chemicals Corporation · US

Inventors

• Thomas Eichenberger · Basel, CH
• Max Hügin · Moutier, CH
• Karl-Heinz Muller · Wissen, DE

Key dates

• Filing date: Oct 13, 2000
• Grant date: Jul 29, 2003
• Expiry date: Oct 13, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B57/00
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

Preparation of pyrimido[5,4-g]pteridine of formula I wherein A1, A2, A3 and A4 are each independently of the others —NR1R2, wherein R1 and R2 are hydrogen, C1-C8alkyl, —CO—C1-C8alkyl, —CO—C6-C14aryl, —COO—C1-C8alkyl, —COO—C6-C14aryl, —CONH—C1-C8alkyl or —CONH—C6-C14aryl, or —OH, —SH, hydrogen, C1-C8alkyl, C1-C8alkoxy, or C6-C14aryl or —O—C6-C14aryl each unsubstituted or mono- or poly-substituted by halogen, nitro, cyano, —OR10, —SR10, —NR10R11, —CONR10R11, —COOR10, —SO2R10, —SO2NR10R11, —SO3R10, —NR11COR10 or by —NR11COOR10, wherein R10 and R11 are each independently of the other hydrogen, C1-C8alkyl, C5-C12cycloalkyl or C2-C8alkenyl, by a) reacting the pyrimidine of formula II with the pyrimidine of formula III in the presence of an acid and, if desired, of a solvent, the molar ratio of the acid to the compound of formula II being in the range of from 100:1 to 1:1, and b) subsequently treating the resulting reaction mixture with a base, and novel pyrimido[5,4-g]pteridine salts and their use.