Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfony)phenyl]ethanone
US6600046B2 · kind B2 · utility
3Cited by
4References
2Claims
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Key dates
| Filing date | Oct 30, 2002 |
| Grant date | Jul 29, 2003 |
| Priority date | — |
| Expiry date | Oct 30, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/50
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The process for preparing 1-(6-methylpyridin-3-yl)-2-[(4-methlsulfonyl)-phenyl]ethanone of the formula I: In a first step, 4-(methylthio)phenylacetonitrile is condensed with a 6-methylnicotinic ester to give 3-[2-(4-(methlthio)phenyl)-2-cyanoacetyl](6-methyl)pyridine of the formula II: In a second step, the compound of formula II is hydrolyzed and decarboxylated under acidic conditions using a mixture of acetic acid and a mineral acid, to give 3-[2-(4-(methylthio)phenyl)acetyl](6-methyl)pyridine of the formula III: Finally, in a last step, the compound of formula III is oxidized to give the end product.
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