Factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt
US6600051B2 · kind B2 · utility
14Cited by
23References
7Claims
0Family size
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Inventor
Key dates
| Filing date | Jun 14, 2002 |
| Grant date | Jul 29, 2003 |
| Priority date | — |
| Expiry date | Jul 22, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A factory scale process for producing crystalline atorvastatine trihydrate hemi calcium salt includes the addition of extra methyl tert-butyl ether to the reaction mixture to supersaturate the crystallization matrix. A seed slurry is made up in a make-up/delivery vessel and delivered, under pressure, to the reaction mixture. The process produces crystalline atorvastatin calcium within a consistent size range on a factory scale.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.