Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic , and medicament containing them

US6600072B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Joachim Brendel · Bad Vilbel, DE
• Heinz-Werner Kleeman · Bischofsheim, DE
• Heinrich Englert · Hofheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Udo Albus · Florstadt, DE
• Bansi Lal · Yellandu, IN
• Anil Ghate · Thane, IN

Key dates

• Filing date: Aug 14, 2002
• Grant date: Jul 29, 2003
• Expiry date: Aug 14, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them.Substituted 1-naphthoylguanidines of the formula Iin which R2 to R8 have the meanings indicated in the claims, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.