Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode

US6602399B1 · kind B1 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Peter Fromherz · Hersbruck, DE
• Elisabeth Meyer · Langenselbold, DE
• Bernhard Straub · Erligheim, DE

Key dates

• Filing date: Mar 22, 2000
• Grant date: Aug 5, 2003
• Expiry date: Mar 22, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/6872
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to bioelectronic devices comprising living cells which are in operative contact with an extracellular planar potential-sensitive electrode, e.g. a field effect transistor. The cells comprise an ion channel/receptor system which is responsive to stimuli. Thus, the device is suitable as a bioelectronic sensor. The electrode may also have a capacitive stimulating spot, with which the electrical or functional state of the cell or its ion channel/receptor system may be affected.