Method and device for collecting and stabilizing a biological sample

US6602718B1 · kind B1 · utility

Assignees

• Becton, Dickinson and Company · US
• QIAGEN GmbH · DE

Inventors

• Frank A. Augello · Cedar Knolls, US
• Lynne Rainen · Maplewood, US
• Matthew Walenciak · Madison, US
• Uwe Oelmüller · Erkrath, DE
• Ralf Wyrich · Grevenbroich, DE
• Helge Bastian · Mettmann, DE

Key dates

• Filing date: Nov 8, 2000
• Grant date: Aug 5, 2003
• Expiry date: Nov 8, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/2525
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A collection container and method for collecting a predetermined volume of a biological sample, and particularly a whole blood sample, includes an effective amount of at least one stabilizing agent. The stabilizing agent is able to stabilize nucleic acids in the biological sample at the point of collection to prevent enzymatic degradation of the nucleic acids. The stabilizing agents include cationic compounds, detergents, particularly cationic detergents, chaotropic salts, ribonuclease inhibitors, chelating agents, and mixtures thereof.