Mercaptoacetylamide derivatives, a process for their preparation and their use

US6602866B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Gary A. Flynn · Cincinnati, US
• Barbara A. Anderson · Cincinnati, US
• Manfred Gerken · Marburg, DE
• Bernd Jablonka · Bad Soden, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Wolfgang Linz · Mainz, DE
• Werner Seiz · Frankfurt am Main, DE
• Bernhard Seuring · Frankfurt am Main, DE

Key dates

• Filing date: Apr 8, 2002
• Grant date: Aug 5, 2003
• Expiry date: Apr 8, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention discloses and claims a series of mercaptoacetylamide derivatives of formula I. Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes for preparing said compounds. The use of said compounds for inhibition of the enzymes angiotensin converting enzyme and neutral endopeptidase, and for the treatment of hypertension and congestive heart failure are also disclosed and claimed