Patent · US Expired

Receptor structures

US6602977B1 · kind B1 · utility

50Cited by

10References

16Claims

0Family size

Assignee

Biovitrum AB · SE

Inventors

Charlotta Ljungqvist · Bromma, SE
Karin Nord · Stockholm, SE
Per Nygren · Helsingborg, SE
Mathias Uhlen · Uppsala, SE

Key dates

Filing date	Apr 14, 2000
Grant date	Aug 5, 2003
Priority date	—
Expiry date	Apr 14, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/1034
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to modified polypeptide derivatives of the B domain or Z domain of staphylococcal protein A (SPA). The derivatives contain amino acid substitutions that result in the ability of the B domain or Z domain to interact with at least one domain of a human Factor VIII protein, without substantially disrupting the structure and stability of the B domain or Z domain.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.