DNA molecule encoding TNF binding ligands and vectors and host cells containing the DNA molecule
US6602993B2 · kind B2 · utility
5Cited by
6References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 8, 2001 |
| Grant date | Aug 5, 2003 |
| Priority date | — |
| Expiry date | Mar 12, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
DNA encoding Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not its binding to the TNF-Rs. Most preferably, the antibodies bind to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor, which loop consists of the amino acid sequence Cys-185 to Thr-201 of SEQ ID NO:3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.