Synthesis of epothilones, intermediates thereto and analogues thereof

US6603023B2 · kind B2 · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• Samuel J. Danishefsky · New Haven, US
• Peter Bertinato · Old Lyme, US
• Dai-Shi Su · New York, US
• Dongfang Meng · Morganville, US
• Ting-Chao Chou · Paramus, US
• Ted Kamenecka · New York, US
• Erik Sorensen · Village of La Jolla, US
• Aaron Balog · Lambertville, US
• Kenneth A. Savin · New York, US
• Scott D. Kuduk · Harleysville, US
• Christina Harris · Troy, US
• Xiu-Guo Zhang · New York, US
• Joseph R. Bertino · Branford, US

Key dates

• Filing date: Feb 1, 2002
• Grant date: Aug 5, 2003
• Expiry date: Feb 1, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1892
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.