Media milling

US6604698B2 · kind B2 · utility

Assignee

• Skyepharma Canada Inc. · CA

Inventors

• Frank Verhoff · Cincinnati, US
• Robert A. Snow · West Chester, US
• Gary W. Pace · Winchester, US

Key dates

• Filing date: May 10, 2001
• Grant date: Aug 12, 2003
• Expiry date: Jun 29, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S0; the large size media have a size distribution S1 of which all are larger than S0; the small size media have a size distribution S2 which are smaller than S0; the very small milled substrate particles have a size distribution S3 and are smaller than all of the small media; and the large s…