Method and composition for inhibiting cardiovascular cell proliferation

US6605115B1 · kind B1 · utility

Assignee

• Board of Trustees of the Leland Stanford Junior University · US

Inventors

• John Cooke · Palo Alto, US
• Garrison C. Fathman · Portola Valley, US
• Jonathan B. Rothbard · Woodside, US
• Shiro Uemura · Nara, JP
• Robert C. Robbins · Stanford, US
• Murray H. Kown · Menlo Park, US

Key dates

• Filing date: Jun 5, 2000
• Grant date: Aug 12, 2003
• Expiry date: Jun 19, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, where at least 50% of the subunits are arginine, and the polymer contains at least six contiguous arginine subunits. Exemplary polymers for this purpose include arginine homopolymers 7 to 15 subunits in length.