Base analogues

US6605611B2 · kind B2 · utility

Assignee

• Nycomed Amersham PLC · GB

Inventors

• Adrian Simmonds · Norton, GB
• Alan Hamilton · Norton, GB
• Clifford Smith · Hertford, GB
• David Loakes · Cambridge, GB
• Daniel Brown · Cambridge, GB
• Fergal Hill · Riom, FR
• Shiv Kumar · Montgomery, US
• Satyam Nampalli · Cockeysville, US
• Mark McDougall · Bethlehem, US

Key dates

• Filing date: Sep 3, 2002
• Grant date: Aug 12, 2003
• Expiry date: Sep 3, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Nucleoside analogues or base analogues having structure (I), where X=O or NH or S, Y=N or CHR6 or CR6, W=N or NR6 or CHR6 or CR6 or S, n=1 or 2; each R6 is independently H or O or alkyl or alkenyl or alkoxy or aryl or a reporter moiety; where necessary (i.e. when Y and/or W is N or CR6 where R6 is not O) a double bond is present between Y and W or W and W, and Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue.