Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them

US6605625B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Stefan Peukert · Frankfurt am Main, DE
• Joachim Brendel · Bad Vilbel, DE
• Horst Hemmerle · Lorsch, DE
• Heinz-Werner Kleemann · Bischofsheim, DE

Key dates

• Filing date: Nov 29, 2001
• Grant date: Aug 12, 2003
• Expiry date: Nov 29, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/82
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I in which: A1, A2, A3, A4, A5, A6, A7 and A8 independently of one another are chosen from nitrogen, CH and CR(5), at least four of these groups being CH, and wherein all other variables are as defined here.