Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them

US6605637B1 · kind B1 · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventors

• Jeremiah Harnett · Gif-sur-Yvette, FR
• Michel Auguet · Palaiseau, FR
• Pierre-Etienne Chabrier de Lassauniere · Paris, FR

Key dates

• Filing date: Sep 27, 2001
• Grant date: Aug 12, 2003
• Expiry date: Sep 27, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D339/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen species (ROS) and intervening in a more general manner in the redox status of thiol groups. The invention also concerns methods for preparing them, pharmaceutical compositions containing them and their use for therapeutic purposes, particularly their use as NO-synthase inhibitors and/or as agents acting more generally in the redox status of thiol groups.