Mirror-symmetrical selection and evolution of nucleic acids

US6605713B1 · kind B1 · utility

Inventors

• Jens Furste · Berlin, DE
• Rolf Bald · Bad Wimpfen, DE
• Volker Erdmann · Berlin, DE

Key dates

• Filing date: Apr 29, 1999
• Grant date: Aug 12, 2003
• Expiry date: Apr 29, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method is disclosed for identifying and producing L-nucleic acids which interact with a target molecule having a natural configuration, as well as the L-nucleic acids produced by this method. Also disclosed is the use of D-nucleic acids which bind to the optical antipode of the target molecule as a matrix for producing L-nucleic acids with an identical sequence, and pharmaceutical compositions and kits which contain the disclosed L-nucleic acids.