Oligonucleotide N3′→P5′ thiophosphoramidates: their synthesis and administration to treat neoplasms
US6608036B1 · kind B1 · utility
38Cited by
23References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 2000 |
| Grant date | Aug 19, 2003 |
| Priority date | — |
| Expiry date | Feb 7, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S−)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3′→P5′ phosphoramidates and to exhibit a much higher acid stability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.