Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment

US6608078B2 · kind B2 · utility

Assignee

• Wockhardt Limited · IN

Inventors

• Noel De Souza · Mumbai, IN
• Mahesh Vithalbhai Patel · Aurangabad, IN
• Shiv Kumar Agarwal · Chennai, IN
• Shirkant V Gupte · Aurangabad, IN
• Dilip J. Upadhyay · Thane, IN
• Satish Bhawsar · Aurangabad, IN
• Mohammad Alam Jafri · Aurangabad, IN

Key dates

• Filing date: May 7, 2001
• Grant date: Aug 19, 2003
• Expiry date: May 7, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo[i,j]quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.