Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

US6608197B2 · kind B2 · utility

Assignee

• Neurocrine Biosciences, Inc. · US

Inventors

• Yun-Fei Zhu · San Diego, US
• Chen Chen · San Diego, US
• Fabio Tucci · San Diego, US
• Zhiqiang Guo · San Diego, US
• Timothy Gross · San Francisco, US
• Martin Rowbottom · San Diego, US
• R. Struthers · Encinitas, US

Key dates

• Filing date: Jan 25, 2001
• Grant date: Aug 19, 2003
• Expiry date: Jan 25, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.