Human DNA mismatch repair proteins

US6610477B1 · kind B1 · utility

Assignees

• HUMAN GENOME SCIENCES, INC. · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• William A. Haseltine · Cambridge, US
• Steven Ruben · Olney, US
• Ying-Fei Wei · Berkeley, US
• Mark D. Adams · Potomac, US
• Robert D. Fleischmann · Gaithersburg, US
• Claire Fraser · Centreville, US
• Rebecca A. Fuldner · Barnesville, US
• Ewen F. Kirkness · Washington, US
• Craig Rosen · Laytonsville, US
• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Nicholas C. Nicolaides · Boothwyn, US
• Nickolas Papadopoulos · Towson, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Aug 26, 2003
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/143333
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.