Screening compounds for the ability to alter the production of amyloid-&bgr; peptide

US6610493B1 · kind B1 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• Athena Neurosciences, Inc. · US

Inventors

• Martin Citron · Thousand Oaks, US
• Dennis J. Selkoe · Brookline, US
• Peter A. Seubert · South San Francisco, US
• Dale B. Schenk · Burlingame, US

Key dates

• Filing date: Jun 18, 1996
• Grant date: Aug 26, 2003
• Expiry date: Jun 18, 2016

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods of screening compounds for their ability to alter the production of A&bgr;(x≧41) alone or in combination with A&bgr;(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of A&bgr;(x≦40) and A&bgr;(x≧41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.