4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors

US6610688B2 · kind B2 · utility

Assignee

• Sugen, Inc. · US

Inventors

• Congxin Liang · North Palm Beach, US
• Li-Qiang Sun · Foster City, US
• Chung Chen Wei · Cedar Knolls, US
• Peng Cho Tang · Moraga, US
• Gerald McMahon · San Francisco, US
• Klaus-Peter Hirth · San Francisco, US
• Jingrong Jean Cui · San Diego, US

Key dates

• Filing date: Dec 21, 2000
• Grant date: Aug 26, 2003
• Expiry date: Dec 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention further relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.