16-Halogen-epothilone derivatives, method for producing them and their pharmaceutical use

US6610736B1 · kind B1 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ulrich Klar · Berlin, DE
• Werner Skuballa · Berlin, DE
• Bernd Buchmann · Hohen Neuendorf, DE
• Wolfgang Schwede · Berlin, DE
• Michael Schirner · Berlin, DE

Key dates

• Filing date: Dec 7, 2001
• Grant date: Aug 26, 2003
• Expiry date: Dec 7, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel epothilone derivatives of general formula (I), wherein R8 means a halogen atom, especially a fluorine or chlorine atom, and the remaining substituents have the meanings given in the description. The novel compounds are suitable for producing medicaments.