Copper-catalyzed enantioselective allylic substitution reactions

US6610871B1 · kind B1 · utility

Assignee

• Avecia Limited · NL

Inventors

• Frank Duebner · Friedberg, DE
• Paul Knochel · Marburg, DE

Key dates

• Filing date: May 3, 2001
• Grant date: Aug 26, 2003
• Expiry date: May 3, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An allylic compound is reacted with an organozinc compound Zn(R6)2 to eliminate a group (the leaving group) from the allylic compound and to add a group from the organozinc compound to it in the presence of a copper salt catalyst and a chiral organic ligand for the copper. A novel ferrocenyl compound and a novel copper complex of the ferrocenyl compound and copper are also described.