Tissue pooling process
US6613278B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 1999 |
| Grant date | Sep 2, 2003 |
| Priority date | — |
| Expiry date | Sep 7, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2310/00976
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biol…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.