Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal
US6613327B1 · kind B1 · utility
2Cited by
4References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 28, 2000 |
| Grant date | Sep 2, 2003 |
| Priority date | — |
| Expiry date | Jul 28, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6863
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of inhibiting and diagnosing spontaneous abortion in a subject are provided. The subject methods are based, inter alia, on the administration of an agent that inhibits a CD28-C mediated costimulatory signal in a T cell such that spontaneous abortion in the subject is inhibited. The subject methods are also based on the levels of adhesion molecules, inflammatory cytokines, and immune cell surface molecules which are altered in spontaneous abortion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.