Method for monitoring proteasome inhibitor drug action
US6613541B1 · kind B1 · utility
47Cited by
5References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 19, 1999 |
| Grant date | Sep 2, 2003 |
| Priority date | — |
| Expiry date | Oct 19, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/948
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.