Tryptase inhibitors

US6613769B1 · kind B1 · utility

Assignees

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US
• ALTANA PHARMA AG · DE

Inventors

• Wolfram Bode · Gauting, DE
• Luis Moroder · Martinsried, DE
• Pedro Jose Barbosa Pereira · Krailling, DE
• Andreas Bergner · Schwanau, DE
• Robert Huber · Midland, US
• Christian Sommerhoff · Hersbruck, DE
• Norbert Schaschke · Hersbruck, DE
• Thomas Bar · Reichenau, DE
• Thomas Martin · Konstanz, DE
• Josef Stadlwieser · Konstanz, DE
• Wolf-Rudiger Ulrich · Konstanz, DE
• Andreas Dominik · Allensbach, DE
• Ulrich Thibaut · Konstanz, DE
• Daniela Bundschuh · Konstanz, DE
• Rolf Beume · Konstanz, DE
• Karl-Josef Goebel · Radolfzell, DE

Key dates

• Filing date: Jan 22, 2001
• Grant date: Sep 2, 2003
• Expiry date: Jan 22, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to bifunctional tryptase inhibitors of formula (I) wherein H1 and H2 comprise a Q group and L is a linker of formula and the conformation of the H1, H2 and L groups is such that the groups are separated by a distance of from 20 to 45 å. Pharmaceutical compositions and crystal forms of the compounds are described in addition to methods for producing and identifying such compounds, as well as the use of such compounds in methods of treating allergic and inflammatory diseases.