&bgr;-polypeptide foldamers of well-defined secondary structure

US6613876B1 · kind B1 · utility

Assignee

• Wisconsin Alumni Research Foundation · US

Inventors

• Samuel H. Gellman · Madison, US
• Daniel H. Appella · Rockville, US
• Laurie A. Christianson · Wilmington, US
• Daniel A. Klein · Madison, US
• Susanne Krauthäuser · Overath, DE
• Yong-Jun Chung · Madison, US
• Xifang Wang · Acton, US

Key dates

• Filing date: Dec 15, 1999
• Grant date: Sep 2, 2003
• Expiry date: Dec 15, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are &bgr;-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the &agr; and &bgr; carbons of the peptide backbone. The &bgr;-peptides adopt stable helical and sheet structures in both the solid state and in solution. Method of generating combinatorial libraries of peptides containing &bgr;-peptide residues and the libraries formed thereby are disclosed.