Synthesis of acyclic nucleoside derivatives

US6613936B1 · kind B1 · utility

Assignee

• MEDIVIR AB · SE

Inventors

• M. Robert Leanna · Grayslake, US
• Steven M. Hannick · Highland Park, US
• Michael Dolberg Rasmussen · Kenosha, US
• Howard E. Morton · Gurnee, US
• Daniel Plata · Wadsworth, US

Key dates

• Filing date: Oct 18, 2000
• Grant date: Sep 2, 2003
• Expiry date: Oct 18, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.